Economic principles in cell metabolism
|Protein allocation||Optimal states||Enzyme cost||Flux cost||Rate and yield|
|Value structure||Kinetic models||Flux analysis||Optimal adaptation||Enzyme rhythms|
Metabolic economics - a theory of optimal metabolic states
Metabolic systems are governed by compromises between metabolic benefit and enzyme cost. This hypothesis and its consequences can be studied by metabolic models in which enzyme profiles follow optimality principles. In optimal metabolic states, active enzymes must provide a benefit: higher enzyme levels must improve the metabolic objective to justify the additional enzyme cost. This entails general relations between metabolic fluxes, reaction elasticities, and enzyme costs. Similar laws hold for flux analysis and models of growing cells. The articles and preprints on this page generalise this principle and describe cellular resource allocation from different perspectives.
"Enzyme economy in metabolic networks"(ICSB 2018)
"An economic network theory of cell metabolism"
- Software code Matlab code / Documentation
Wolfram Liebermeister (2020)