Economic principles in cell metabolism

Metabolic systems are governed by compromises between metabolic benefit and enzyme cost. This hypothesis and its consequences can be studied by kinetic models in which enzyme profiles are predicted by optimality principles. In enzyme-optimised states, active enzymes must provide a benefit, that is, higher enzyme levels must improve the metabolic objective to justify the additional enzyme cost. This entails general relations between metabolic fluxes, reaction elasticities, and enzyme costs.

Metabolic economics

Economic flux analysis

Enzyme rhythms

Project "An economic network theory of cell metabolism"

Poster "Enzyme economy in metabolic networks", 2014

Further projects by Wolfram Liebermeister