Economics of periodic enzyme activities
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Cost-coupled enzymes (fast adaptation)
This model is a variant of the single-reaction model. There is an additional reaction with fixed reactant levels, and the two enzymes are effectively coupled by a non-linear costs function. The first enzyme is periodically adapted to its substrate and promotes an (anti-phasic) rhythm in the second enzyme.
| Forced oscillation (without adaptation) | Forced oscillation (with adaptation) |
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Squares: enzyme levels Circles: metabolite levels