Economics of periodic enzyme activities
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Optimal enzyme oscillations: ROS production and DNA synthesis
This model illustrates a hypothesis about metabolic oscillations in yeast: that respiration, by producing both ATP and reactive oxygen species (ROS) is both necessary and harmful DNA synthesis; and that this contradiction can be solved by a "temporal compartmentalization", in which (in a temporal order) ATP and ROS are produced, ROS are removed, and DNA is synthesised. The model confirms that a spontaneous enzyme rhythm, by partially separating the different processes, can lead to a fitness advantage.
| Forced oscillation (without adaptation) | Spontaneous rhythm |
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Squares: enzyme levels Circles: metabolite levels